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KMID : 0352419930120020149
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Keimyung Medical Journal
1993 Volume.12 No. 2 p.149 ~ p.159
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GABA-ergic and Dopaminergic Influences on the Changes of Plasma Corticosterone Concentration by Diazepam in mice
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김수경
이미은
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Abstract
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One of the benzodiazepines, diazepam, has been widely used as anxiolytic, muscle relaxant, and anticonvulsant. These various pharmacologic actions of diazepam have been known to be largely dependent on the benzodiazepine and gamma-aminobutyric
acid(GABA) receptor.
In our study, we observed the diazepam-induced alteration of plasma corticosterone concentration and the effects of GABA-ergic or dopaminergic agonist and antagonists on the diazepam-induced change of plasma corticosterone concentration. And we
compared
diazepam with other benzodiazepines, clonazepam and flunitrazepam which have different affinities for central and peripheral benzodiazepine receptors.
As a results, the plasma corticosterone concentration was significantly increased by diazepam. The diazepam-induced increase was inhibited by muscimol and baclofen. And the effects of muscimol and baclofen in diazepam were not affected by
administration
of ACTH. Picrotoxin potentiates the increase of diazepam-induced plasma corticosterone concentration. The diazepam-induced increase of plasma corticosterone concentration was inhibited by apomorphine and petentiated by haloperidol. The effects of
apomorphine and haloperidol were potentiated by administration of ACTH. Clonazepam and flunitrazepam produce the increase of plasma corticosterone slightly. Clonazepam or flunitrazepam-induced increase was inhibited by muscimol and baclofen. The
effects
of muscimol and baclofen on corticosterone concentration were antagonized by ACTH. Clonazepam or flunitrazepam-induced change of plasma corticosterone concentration was not affected by apomorphine and increased by haloperidol. The effects of
apomorphine
were antagonized by administration of ACTH and was potentiated by haloperidol. The plasma corticosterone level was increased by diazepam more than clonazepam or flunitrazepam and this action of diazepam may be dependent on the affinities to the
peripheral and central BZD receptors.
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KEYWORD
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